This research work was conducted to assess the antioxidant effect of vitamin E on hydrogen peroxide and nitrogen oxide levels. 24 albino rats were divided randomly into six groups of four test animal per group. Group A served as control and were given normal rat chow and water. Group B served as trypanosome treated and were infected with 1×106 trypanosome. Group C were infected with 1×106 trypanosome and treated with the standard drug (diaminazene acetuate). Group D were infected with 1×106 trypanosome and treated with 0.1mg/kg body weight of vitamin E (low dose). Group E were infected with 1× 106 trypanosome and treated with 0.5mg/kg body weight of vitamin E (moderate dose). Group F were infected with 1×106 trypanosome and treated with 1.0mg/kg body weight (high dose) for 14 days. Hydrogen peroxide and nitric oxide were assayed by scavenging Assay methods. The result of this study shows that hydrogen peroxide levels showed a significant difference (p<0.05) when compared with value of 0.31±0.03 of the control except with groups treated with 0.5mg and 0.1mg of vitamin E which showed no significant difference (p>0.05) with values of 0.36±0.03 and 36±0.03 respectively. However, nitric oxide levels showed significant difference (p>0.05) when compared with value of 21.44±0.91 of control except group treated with 0.5mg of vitamin E which showed significant difference (p<0.05) with value of 17.09 ±0.00. The findings from this study therefore show that Vitamin E caused changes in Hydrogen peroxide and Nitric oxide levels based on the concentration of the vitamin E.

There has been no reported study on the awareness and acceptability of Human Papilloma Virus (HPV) vaccination among
female University students and antenatal mothers in Port Harcourt. HPV has been implicated as the highest risk factor for cervical
cancer. Reports have shown that the vaccine prevents a high percentage of cervical cancer. This study was carried out to assess the level
of awareness and acceptance of HPV vaccine amongst female undergraduate students and Antenatal (ANC) mothers in Port Harcourt.A
descriptive cross-sectional study was conducted among 800 participant; 436 female undergraduates and 364 ANC mothers.The Level of
HPV awareness was poor, but the level ofHPV vaccine acceptability was high. Enlightenment programs and public health promotion
talk on HPV and HPV vaccination among female undergraduate students and ANC mothers should be encouraged. Context: There has
been no reported study on the awareness and acceptability of Human Papilloma Virus (HPV) vaccination among female University
students and antenatal mothers in Port Harcourt. HPV has been implicated as the highest risk factor for cervical cancer. Reports have
shown that the vaccine prevents a high percentage of cervical cancer. Objective: To assess the level of awareness and acceptance of
HPV vaccine amongst female undergraduate students and Antenatal (ANC) mothers in Port Harcourt. Method: A descriptive crosssectional
study was conducted among 800 participant; 436 female undergraduates and 364 ANC mothers. The University of Port
Harcourt and the Braithwaite Memorial Specialist Hospital (BMSH) in Port Harcourt was used to obtain data from female
undergraduates and registered ANC mothers respectively. Recruitment of students was by random and systemic sampling and
recruitment for ANC mothers was based on routine antenatal check-up. A self- administered questionnaire was used to obtain relevant
information from participants. Results: Level of HPV awareness was poor, but the level ofHPV vaccine acceptability was high.
Conclusions: Enlightenment programs and public health promotion talk on HPV and HPV vaccination among female undergraduate
students and ANC mothers was necessary. Recommendation: HPV vaccination should be part of the health evaluation of all female
students at entry point and a HPV vaccination program should be included for ANC mothers in health facilities.

The focus of current research study was to evaluate the influence of the
seed extract of Citrullus lanatus on urea, creatinine, potassium, sodium,
chloride and bicarbonate in streptozotocin induced diabetic rats.
Eighteen male wistar albino rats were divided into six groups of three
rats each, diabetes were induced in all the rats except group 1 by intraperitoneal
injection of 45 mg/kg b.wt. of streptozotocin. Group 1 rats
served as control and received standard feed and water daily; Group 2
rats received oral Glibenclamide (0.5 mg/kg bw); Group 3,4, and 5
received 200 mg/kg bw, 400 mg/kg bw and 600 mg/kg b.wt. of the
ethanolic extract of Citrullus lanatus seed respectively; and group 6
served as diabetic group. Blood samples were collected and analysed for
urea, creatinine, potassium, sodium, chloride and bicarbonate using
urease-Berthelot colorimetric method, Jaffe’s colorimetric method and
Ion selective electrode (ISE) method respectively. There was a significant
decrease in (p<0.05) glucose concentration (mmol/L) of 3.90 in control compared to 8.07, 8.73, 14.67, 11.43 and 9.80 in albino rats treated with glibenclamide, STZ+CLS 200 mg, STZ+CLS 400 mg, STZ+CLS 600 mg and diabetic control respectively. In potassium concentration (meq/l) 6.51 in control compared with 4.97, 7.59, 7.28, 8.45 and 6.87 in albino rats treated with glibenclamide, STZ+CLS200 mg, STZ+CLS 400 mg, STZ+CLS 600 mg and diabetic control respectively. While in sodium concentration (meq/l) of 1.42 in control compared to 1.33, 1.30, 1.36, 1.42 and 1.36 in albino rats treated with glibenclamide, STZ+CLS 200 mg, STZ+CLS 400 mg, STZ+CLS 600 mg and diabetic control respectively. However, in chloride concentration (meq/l) of 1.06 in control compared to 99.10, 97.87, 1.04, 88.00, 1.04, 88.00 and 1.04 in albino rats treated with glibenclamide, STZ+CLS 200 mg, STZ+CLS 400 mg, STZ+CLS 600 mg and diabetic control respectively and also in bicarbonate concentration (meq/l) of 10.07 when compared with 17.30, 16.47, 15.40, 6.40 and 17.30 in albino rats treated with glibenclamide, STZ+CLS 200 mg, STZ+CLS 400 mg, STZ+CLS 600 mg and diabetic control respectively. In conclusion, this medicinal plant could be considered as a potential and alternative approach for the treatment of diabetes.